One Year Anniversaries and Fat Sequestering Nutraceuticals: the Latest 1 Million Cups Rochester

 Jake Orme of LipiQuester at February's 1 Million Cups Rochester.

Jake Orme of LipiQuester at February's 1 Million Cups Rochester.

This week at 1 Million Cups Rochester, the community celebrated the one-year anniversary of the program in this community. Jake Orme, a physician at Mayo Clinic, also presented his anti-obesity product, LipiQuester.

1 Million Cups has served as a “supportive, neutral place” to share stories of startup development for the past twelve months in Rochester. The program is industry agnostic; over twenty-two groups have presented their business in Rochester so far on this platform. This upcoming year, the 1 Million Cups Rochester organizers are working to refine and improve the vetting and coaching process for companies applying to the 1 Million Cups Rochester program. The organizers also look to provide better follow up with past presenters for the Rochester community.

Over the past year, 1 Million Cups Rochester has had diverse impact leading to: access to enterprise customers, job offers, sales leads, improvement for future presentations, company awareness in the community, pivots, and mentorship opportunities.

The program focused on one presenter this month, Dr. Jake Orme of LipiQuester.

Orme is developing a product that captures and sequesters fat from digested food within the gut, preventing fats from interacting with bacteria and causing negative side effects. 

Over one-third of American adults are obese, according to the Centers for Disease Control and Prevention. The first line of defense to treat obesity, Orme explained, is diet and exercise. However, this route is successfully sustained in only one out of ten people.

“Round two [of treatment] involves medications that aren’t that great,” he said.

This second line of defense includes drugs, like Orlistat, that prevent the body from breaking down fat. However, patients typically do not stay on these therapies for too long as they can lead to diarrhea, massive flatulence, and anal leakage.

Orme believes his product, LipiQuester, serves as a better solution than current drugs on the market to treat obesity. LipiQuester is a type of nutraceutical made of “thousands of tiny whiffle balls.” The outside matrix of these biodegradable, microscopic particles is similar to products like MiraLax, adding fiber to the diet. The inside of the matrix contains a hydrophobic resin that grabs and retains fats, eliminating them from the body.

LipiQuester has little taste and forms a suspension in water.

Orme’s team performed a small pilot study with the product in mice. LipiQuester prevented gains in body fat percentage in mice on high fat diets compared to animals that were not fed the product. The team is now looking to raise $10M to get LipiQuester onto the market, hopefully through the food additive pathway.

The next 1 Million Cups Rochester will take place on Wednesday, March 7th at 9 AM in the Bleu Duck Kitchen Event Space.

1 Million Cups is a free, national education program developed by the Kauffman Foundation. 1 Million Cups takes place every Wednesday at 9AM across 165 US communities to support and encourage entrepreneurs. The program is based on the idea that entrepreneurs connect and discover solutions over one million cups of coffee