Ambient Clinical Analytics

Local Businesses Ambient Clinical Analytics and FAVR Inc. Share their Startup Stories at Latest 1 Million Cups Rochester

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Last week two local startups earned the spotlight at 1 Million Cups Rochester: Ambient Clinical Analytics and FAVR Inc. Ambient Clinical Analytics, led by CEO Al Berning, is a digital health startup delivering innovative bedside predicative analytics. FAVR, an app-based tech startup led by CEO Solomon Antoine, serves as a peer to peer platform allowing customers to request a task at their own set price.

Serial entrepreneur Berning has started four companies in the last twenty-five years including LiquidCool Solutions, a Rochester company developing cooling solutions for electronics, and Pemstar, an electronics manufacturing firm. Berning’s newest startup, Ambient Clinical Analytics, is based on Mayo Clinic technology, which was developed over the past ten years in the Mayo Clinic ICU and emergency departments. Ambient Clinical Analytics sells real time clinical decision-making support tools to reduce clinical staff decision rate time and to eliminate errors. The startup has been in operation for five years selling to hospitals and hospital systems across the globe. The company has raised $7M in funding to date and is in the process of closing a $1M convertible note bridge round. Ambient Clinical Analytics has four products on the market, all aimed to reduce information overload on clinical caregivers and to organize and present data to enable rapid and informed clinical decision making. 

FAVR Inc.’s iOS app connects users with freelance workers to perform on demand lawn care and home chores. The app solves the users’ need to complete these tasks without use of their limited time while allowing a younger demographic of freelancers to earn money in their spare time. FAVR fills a unique space, allowing users to request tasks at their own set price. The app currently has two hundred fifty users on the platform, including customers and freelancers, all based in Rochester. The startup plans to expand its reach into four communities with a strong college base including Minneapolis, Brookings, Winona, and Mankato.

1 Million Cups is an educational event for entrepreneurs that takes place in one hundred eighty-two communities across the United States. 1 Million Cups Rochester occurs the first Wednesday of every month at 9AM in the Bleu Duck Kitchen event space. Join the community at the next event on Wednesday June 5th to hear the stories of two more entrepreneurs in our ecosystem.

Three Healthtech Teams Win Big at Sixth Walleye Tank

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This Friday, twenty-three different biotech teams traveled to Rochester to compete in the sixth Walleye Tank business pitch competition. This packed house event, organized by the Mayo Clinic Office of Entrepreneurship and the Collider Foundation, not only served as a pitch contest. The event additionally brought together multiple pieces of the entrepreneurial ecosystem including venture capitalists, accelerator programs, medical experts, serial entrepreneurs, and business supportive services. In the end, Twin Cities companies NovoClade and ClinicianNexus and Mayo Clinic Florida team The QT Grid walked away as divisional winners. 

Teams competed in three different divisions at Walleye Tank based on stage of business development.

 

Junior Anglers

The first division, the Junior Anglers, included teams in the ideation phase of development who did not yet have a prototype. Nine different teams participated as Junior Anglers at the winter Walleye Tank, the largest group in the competition. 

Adjustable Fracture Nail team from Mayo Clinic Florida won second place in this division. Presented by Mayo Clinic Graduate School student Chris Mehner, Adjustable Fracture Nail targets the 15M patients suffering from long bone fractures in the US each year. These patients are typically treated by insertion of a single, non-adjustable nail into the bone to stabilize the fracture. This process, Mehner explained, it highly dependent on the surgeon’s expertise, resulting in 40% of fracture patients receiving a rotational error of the long bone. This additionally affects bone healing and may lead to joint issues. To solve this problem, the team is creating an adjustable nail containing an internal mechanism to extend the fracture line in the long bone. The nail would also utilize a laser-guided mechanism to finely adjust long bone rotation to the perfect angle. The team believes this product will produce reduced errors, lower surgical time, and decreased medical costs. They currently have a provisional patent on their design. 

Winning the Junior Angler division was the Twin Cities genome editing startup NovoClade. Presented by University of Minnesota-Twin Cities Senior Research Scientist Siba Das, NovoClade is developing SMART technology to control mosquito populations. Current insect management solutions, Das explained, are toxic and not species specific. NovoClade aims to genetically edit mosquito eggs to remove disease carrying insects from the population. The team of four leading the startup include University of Minnesota researchers with over eighty years of combined expertise in genome editing.

 

Mid-Level Reelers 

The second category, the Mid-Level Reelers division, included startups with a prototype or minimally viable product. These companies may or may not have product sales. Eight different teams competed in this division. 

Taking home second place in the Mid-Level category was Twin Cities startup Morari Medical. This startup, presented by healthcare marketing expert Jeff Bennett, addresses the number one male sexual dysfunction, premature ejaculation. Premature ejaculation affects one in three men and can negatively impact quality of life. The Morari Medical team seeks to treat this condition using neuro-modulation based devices to block or delay ejaculation. Neuromodulation is an evolving therapy that alters nerve activity, through chemical or electrical stimuli, at specific nerve sites in the body. With an estimated market size of $15M, Morari Medical is in the early feasibility prototyping stage of development.

Winning the Mid-Level Reeler division was Mayo Clinic Florida innovation The QT Grid. Presented by Postdoctoral Fellow Karim ReFaey, The QT Grid targets the 50M people across the world suffering from epilepsy. Epilepsy, a condition leading to changed electrical activity in the brain, can be caused by stroke, injury, or tumors on the brain or spinal cord, called gliomas. During surgery to remove these gliomas, surgeons also need to monitor electrical activity of the brain through recording electrodes. However, the monitoring devices currently on the market are either too expensive, too cumbersome, or lack complete functionality to perform these tasks. To solve this problem, this team has developed The QT Grid, a ring shaped, patented, and FDA cleared device that allows for 360-degree electrode recordings and readings from all desired areas of the brain simultaneously. The grid is additionally cheaper and more effective than other devices on the market, ReFaey explained.

 

Professional Division 

The final division, the Professionals, were established companies making sales and may be in fundraising mode. This division had six total participants.

Earning second place in the Professional division was Rochester company Ambient Clinical Analytics. Presented by CEO Al Berning, Ambient Clinical has developed a suite of clinical support tools. These solutions address information overload and physician burnout in healthcare settings by taking digital health data, sorting the data, and providing healthcare staff with the 1-5% of the data needed to make an informed decision. These SaaS products received Class II FDA clearance from the FDA. The products are sold on a subscription basis and are in worldwide use. Since launch of the company, Ambient has raised ~$8M to fuel business growth.

Taking home the win in the Professional division was Twin Cities company ClinicianNexus. Presented by CEO Katrina Anderson, this company is targeting the >1M medical students, daily, seeking a clinical rotation experience in over 500K clinical sites in the US alone. Traditionally this matching process is driven by the medical schools using technology as simple as a crowded excel sheet. The ClinicianNexus solution, a collaborative clinical education management tool, assists healthcare sites to proactively address their capacity to teach students; this information can then be shared with medical schools and students seeking to rotate at that particular medical location.

Competing Walleye Tank teams were judged by seasoned entrepreneurs, or “Walleyes,” including: Carla Pavone, Associate Director of the Holmes Center for Entrepreneurship; Perry Hackett, CEO at Recombinetics; Julie Henry, Enterprise IP Manager at Mayo Clinic; Mark Laisure, CEO at Vortex Media; Pam York, General Partner at Capita3; Bryan Clark, Fellow, Corporate Research at Boston Scientific; Dan Cunagin, Managing Partner at Invenshure; and Fernando Bazan, biotech expert. 

Rochester startup Nanodropper won the first ever Audience Favorite Award. This company, led by Mayo Clinic Medical Student Allisa Song, is developing a universal eye dropper adapter that administers the correct size of medical eye drops to reduce prescription waste.  

Teams fed into Walleye Tank from four different funnels including an open application, a Mayo Clinic Florida Alligator Tank, DMC’s Assistive Tech Challenge, and a Student Entrepreneurial Showcase. 

The next Walleye Tank will be held on May 3rd at the University of Minnesota-Twin Cities.

The State of the Rochester Entrepreneurial Community- 2018

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As we transition into another year, it is a prime opportunity to examine the state of the Rochester entrepreneurial community, take stock of our achievements over the past year, examine our losses, and assess the future direction of this city’s innovation sector.

2017 brought several significant ongoing programs to Rochester. February saw the launch of 1 Million Cups Rochester, a monthly educational program for entrepreneurs that takes place in 163 communities across the United States. This event gave fourteen different Rochester startups the opportunity to share their story and gain input from the community on pressing business issues. November brought Rochester’s first full Startup Weekend, a 54-hour event where teams went from idea to a working prototype over a single weekend. Rochester also participated in Global Entrepreneurship Week for the fifth time this year, attracting over five hundred attendees across eighteen different events. The week was also officially proclaimed Entrepreneurship Week in Rochester by Mayor Brede. 

This year, two Rochester tech companies, Brandhoot and Xylo Technologies, were nominated for the U.S. Chamber of Commerce’s 2017 Dream Big Small Business of the Year Awards, a significant honor for the community. In 2017 Binding Site, a global immunodiagnostic and instrumentation company, established a facility in northwest Rochester. This summer we also saw the addition of several new flights at Rochester International Airport, creating increased opportunity for business travel out of Rochester and improved connectivity to the global workforce.

In 2017 the entrepreneurial community experienced positive momentum in funding, with hopes to continue this trend in 2018. In August, Rochester Area Economic Development, Inc. (RAEDI) announced the launch of the Southeast Minnesota Capital Fund to provide equity financing for startup development. While the new fund has not yet made any investments, Rochester companies raised over $17.5M in 2017 (according to Crunchbase), which includes a $5.4M Series A funding round by Ambient Clinical Analytics, as well as additional private equity and venture capital raises. RAEDI’s startup seed capital fund, the Economic Development Fund, to date has invested in fifteen local companies, of which eighty-two percent are women or minority owned. On the state-wide level, 2017 saw a record number of investments in Minnesota’s Medical Alley with $735M raised by eighty-five companies. 

Growth in Destination Medical Center’s Discovery Square sub-district also occurred over the past year. The district now has six current projects, including the Mortenson Building, the first new construction building in Discovery Square. Groundbreaking at this site occurred in November.

This year also brought a general increased interest in entrepreneurship within Rochester and increased coverage of this community by the city’s traditional news media. We also experienced increased organization of Rochester’s innovation sector with a larger number of local organizations beginning to partner with the city’s entrepreneurial community. One example of this increased connectivity was manifested in June, when Vic Gundotra and Dave Albert, senior leaders of the Silicon Valley healthtech company AliveCor, shared their stories of risk and uncertainty in an open forum with Rochester entrepreneurs.

Our entrepreneurial sector also experienced losses in 2017. Perhaps one of the most significant was the exit of architect Adam Ferrari, a leader in the creative community who designed inspiring spaces like Collider Coworking, Grand Rounds Brew Pub, Forager Brewing, Cube, and Café Steam where people could connect, learn, and build businesses. This year also saw the acquisition of Rochester startup Able, a tech startup that built software for farmers by farmers, which resulted in the dissolution of the startup and loss of four local tech jobs.

Although the community had setbacks this past year, 2018 offers opportunity. We look forward to potential increased international and national interest in Rochester, especially in the Discovery Square sub-district as it continues to grow. We also hope to see increased investment in Rochester-based companies and to experience continued recognition as an emerging biotech hub.

Special thanks to Jamie Sundsbak, Community Manager at Collider Coworking, and Xavier Frigola, Director of Entrepreneurship at RAEDI, for their input on the state of the Rochester entrepreneurial community.

Five Rochester Health and Wellness Startups Honored by Minnesota Business Magazine

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This month five Rochester businesses were honored by Minnesota Business Magazine as “Innovators in Health and Wellness” to celebrate local leadership.

Awards were given in sixteen different categories including: Startup, Software Web Application, Health and Wellness Campaign, Excellence in Facility Design, Health Care Executive, Medical Breakthrough, and Wellness Advocate.

Four Rochester businesses or startups were finalists in their respective categories and one local business came away as the overall winner in their division.

Charter House- Mayo Clinic Retirement Living was a finalist in the Health and Wellness Campaign Division.  Charter House is a senior living facility in downtown Rochester, operated by Mayo Clinic, that advocates for healthy aging.

Healthtech startup OneOme was a finalist in the Medical Breakthrough category. OneOme’s solution, called RightMed, is a gene panel that analyzes patient DNA to determine how an individual will respond to medications for a wide range of conditions. The company was co-founded by Troy Kopischke, a managing partner of the Twin Cities incubator Invenshure, and John Black, a consultant in the Division of Clinical Biochemistry and Immunology at Mayo Clinic.

Joselyn Raymundo, Founder at Rochester Home Infusion, was a finalist in the Emerging Leader category. Rochester Home Infusion is the only home infusion provider in southeastern Minnesota, providing many in-home therapies including anti-infective, immunoglobulin therapy, transplant therapy, and pain management.

Ambient Clinical Analytics was also a finalist in the Excellence in Data Analytics category. Ambient Clinical Analytics leverages Mayo Clinic technology in clinical decision support tools to lower healthcare costs and improve patient outcomes. This Rochester-based company is led by CEO and serial entrepreneur Al Berning.

Rochester startup Geneticure was the overall winner the Startup division. Geneticure takes the guessing out of hypertension drug treatment. This company developed a comprehensive panel of genes to analyze patient DNA and determine an individual’s response to certain drug treatments to tailor therapy. Geneticure was founded by Rochester natives and brothers Scott and Eric Snyder. University of Arizona genomics expert Ryan Sprissler and Mayo Clinic Professor of Medicine Thomas Olson are also on the Geneticure founding team.

Press Release: Bringspring Meehealth and Ambient Clinical Analytics Sign Cooperation Agreement in Beijing

Al Berning, CEO of Ambient Clinical Analytics and Dr. Zhang Jiwu, CEO of Meehealth. Photo courtesy of Ambient Clinical Anaalytics. 

Al Berning, CEO of Ambient Clinical Analytics and Dr. Zhang Jiwu, CEO of Meehealth. Photo courtesy of Ambient Clinical Anaalytics. 

Beijing, China – October 26, 2017 Ambient Clinical Analytics announced today that it has signed a Cooperation Agreement with Meehealth (The wholly owned subsidiary company of Bringspring Technologies Co., Ltd, hereinafter referred to as Bringspring Meehealth or Meehealth) in Beijing. Bringspring Meehealth plans to sell Ambient Clinical’s products in China and the companies plan to develop new products for China and the world markets. Founded by a Mayo Clinic academic clinical team and seasoned technology entrepreneurs, Ambient Clinical is located in Rochester, MN, USA. Ambient Clinical’s software enhances the way critical care providers operate. The company sells real time clinical decision support systems and alerting tools to hospitals which result in reduced errors, lower health care costs, and improved patient outcomes. 

"Bringspring Meehealth and Ambient Clinical met in the United States in 2014. Bringspring Meehealth has an international professional team and culture, and places a high value on technological innovation and product quality. Meehealth is honored to cooperate with excellent partners such as Ambient Clinical. “Benefiting society and benefiting mankind is the mutual mission and foundation of the cooperation, and the companies will jointly contribute to the development of world health service." said Dr. Zhang Jiwu, CEO of Meehealth. 

“At Ambient Clinical Analytics, we’re excited to be working with Bringspring Meehealth to cooperate on products for China and the world health IT markets”, said Al Berning, CEO of Ambient Clinical Analytics. “Bringspring Meehealth’s strong support of hospitals across China combined with Ambient Clinical’s products, which are based on Mayo Clinic technologies, make a strong combination to improve healthcare through the use of advanced real time clinical decision support products.” 

“We’re looking forward to working with Bringspring Meehealth and Ambient Clinical to deploy the unique Mayo Clinic real time clinical decision support technology in China.” said Brian Pickering, M.B., B.Ch., of Mayo Clinic, one of the co- inventors of the technology. 

"Bringspring Technology acquired Meehealth, which is the industry's leading health IT company, supporting the company's leading edge in the field of clinical application subdivision. Meehealth has established a cooperative relationship with Ambient Clinical, and we are very pleased and excited about the future. We will fully support and have full confidence in the development of the companies’ cooperation." said Qi Zheng, the vice president of Bringspring Technology. 

Bringspring Meehealth are health care high-tech enterprises with an international perspective, the domestic first-class level, with research focused on medical software products and leads the market by operating room, ICU, emergency department and other clinical information application market customers across the well-known 3A hospitals. With strong technical ability in data processing, data modeling and system architecture design, the company has entered the medical health big data, artificial intelligence and other innovative research applications, relying on the research center in Boston in the United States and the international first-class scientific research talents, Bringspring Meehealth has made remarkable achievements in the research of the health care field, with a mission to improve the efficiency and quality medical services and improve health outcomes. 

Ambient Clinical has licensed Mayo Clinic technologies which include over 1,000 rules and algorithms to give critical care providers real-time access to vital process-of-care information and analytics at the point-of-care, as well as from a central Clinical Control Tower. The CERTAIN product provides critical clinical resuscitation information in the first “Golden Hours” of critical care. Bedside based alerts for conditions like Sepsis allow physicians and medical personnel to spend more time with patients rather than reviewing data. Ambient Clinical’s products are designed to support a hospital’s Lean Quality and Six Sigma initiatives. Ambient Clinical has achieved FDA Class II Clearance for the AWARE and Sepsis DART software platform. 

Mayo Clinic and Dr. Brian Pickering have a financial interest in the technology referenced in this news release. The revenue that Mayo Clinic receives is used to support its not-for-profit mission in patient care, education and research. 

About Bringspring Meehealth
Bringspring (300290) is a technology listed company established in 2005. Driven by ongoing innovative, focus on health data and intelligent cloud services areas. We have established a cutting-edge technologies portfolio in cloud computing, big data, internet of things, artificial intelligence and service. With more than ten years efforts, Bringspring is committed to building a better intelligent and healthier world, and we have grown into a considerable investment value and development potential company. In 2017, company jointly launched the China health big data Limited company, led by National Health and Family Planning Commission, to build a healthy medical big data ecosystem. Meehealth is a leading Health IT company that supports hospitals across China. It has from the world's leading technology and management team, to provide emergency clinical information system (ECIS), Intensive Care Clinical Information System (ICIS), Anesthesia Clinical Information Management system (AIMS), Hospital Unified information Solution (HUIS), mobile Ward Rounds system and the medical industry IT system products , combined with cloud computing, big data, networking, AI and other new generation of information technology to provide the critical patients cloud platform, regional emergency for overall customer collaborative cloud platform and other medical information solutions. In 2016, Bringspring wholly owned Meehealth, has strengthened the company's leading edge in the field of clinical application subdivision. Bringspring integrates high-quality resources, and actively explore the clinical medicine artificial intelligence and big data application platform, build health care big data ecosystem, and promote more intelligent health new service model. 

About Ambient Clinical Analytics
Ambient Clinical Analytics sells powerful real-time bedside healthcare data assimilation, communication, and analytics based clinical decision support tools that support the general hospital floor, Emergency Department, ICU and other critical care areas. At Ambient Clinical Analytics, we understand the power of data to save lives and our analytics based, real- time, point-of-care solutions like Sepsis DART rely on real-time data to improve Sepsis detection and the monitoring of Sepsis treatment. Our business model is supported by software license fees, SaaS, Cloud and system integration support. Ambient Clinical Analytics has an MD and executive team with strong track records in medicine, clinical research and informatics, medical products and IT. Ambient Clinical’s investors include Social Capital, Mayo Clinic, Waterline Ventures, Bluestem Capital, Rock Health and Rochester Area Economic Development Inc.

Press Release: Ambient Clinical Analytics Announces the Close of a $5.4M Series A Funding Round to Drive Growth in its Clinical Decision Support and Control Tower Software Platform

Posted by Ambient Clinical Analytics  on April 27th, 2017

ROCHESTER, MN – Ambient Clinical Analytics announces today that it has completed a $5.4M Series A Funding Round led by Waterline Ventures and Bluestem Capital, with participation from Social Capital. Founded by a Mayo Clinic academic clinical team and seasoned technology entrepreneurs, Ambient Clinical Analytics’ software enhances the way critical care providers operate. The company sells clinical decision support and alerting tools to hospitals which result in reduced errors, lower health care costs, and better patient outcomes

“With FDA Class II Clearance, and the collaboration with Philips on AWARE® for their IntelliSpace Console Critical Care product, Ambient Clinical is in a great positon to grow the market for our Mayo Clinic developed analytics based clinical decision support tools,” explains Al Berning, CEO, Ambient Clinical Analytics. “We’re excited to be starting a partnership with Waterline Ventures and Bluestem Capital, both with extensive experience in Health IT. With the Series A funding, Ambient Clinical is in the process of expanding its sales, marketing and product development activities.”

“We are excited to be working with a highly experienced team at Ambient,” said Robbie Greenglass, Managing Director, Waterline Ventures. “They have positioned the company to be extremely impactful in changing the way emergency departments and intensive care units visualize important information about patients in real time. Ambient pulls data from the EMR and displays it in intuitive, easy to read ways, so that clinicians can focus on patients’ needs.”

“Ambient Clinical Analytics’ clinical decision support software solves a key problem for all critical and emergency care units,” said Tyler Stowater, Partner and Vice President, Bluestem. “Mayo Clinics’ extensive research and Ambient Clinicals ability to support FDA Class II clearance and launch products to the market, is a powerful combination.”

Ambient Clinical uses licensed Mayo Clinic technologieswhich include over 1,000 rules and algorithms, to give critical care providers real-time access to vital process-of-care information and analytics at the point-of-care, as well as from a central Clinical Control Tower.  Bedside based alerts for conditions like Sepsis allow physicians and medical personnel to spend more time with patients instead of reviewing information.  Ambient Clinicals’ products are designed to support a hospital’s Lean Quality and Six Sigma initiatives. Ambient Clinical has achieved FDA Class II Clearance for the AWAR and Sepsis DART software platform.

Ambient Clinical Analytics’ core offerings include:

AWARE is a clinical software tool that reduces information overload by using analytics to filter relevant patient data and provide timely, actionable information. Created by clinicians for clinicians, AWARE clearly and concisely presents actionable information to all care team members to improve patient outcomes, reduce the cost of care, and support best-care practices for ICUs and other critical care areas.

Sepsis DART uses customer-defined sepsis detection and support rules to indicate that sepsis may be present or developing. With algorithms created in conjunction with Mayo Clinic clinicians to comply with CMS requirements, DART alerts caregivers that sepsis may be present or developing and monitors treatment progression during the critical first six hours of care. The solution also supports quality and CMS reporting requirements.

Mayo Clinic YES Board® is a multi-patient management tool that provides real-time situational awareness for Emergency Departments and hospital Pediatric departments. The solution provides real-time patient information in an at-a-glance overview format that ensures care teams have ready access to clinically relevant information.

To learn more about Ambient Clinicals’ transformational products visit:     www.ambientclinical.com

Prior to the Series A funding round, Ambient Clinical received $2.9 million in seed funding from Social Capital, Mayo Clinic, Rock Health, Rochester Area Economic Development Inc., Southern Minnesota Initiative Foundation, Gopher Angels and angel investors. The seed funding was converted to Series A preferred stock at the closing.

About Ambient Clinical Analytics

Ambient Clinical Analytics sells powerful real-time bedside healthcare data assimilation, communication, and analytics based clinical decision support tools that support the general hospital floor, Emergency Department, ICU and other critical care areas. Our business model is supported by software license fees, SaaS, Cloud and system integration revenue. Ambient Clinical Analytics has an MD and executive team with strong track records in medicine, clinical research and informatics, medical products and IT.   Additional information about Ambient Clinical Analytics and AWARE indications for use can be found by visiting: www.ambientclinical.com.

About Waterline Ventures

Waterline Ventures invests in the early stage healthcare technology and services companies that are improving the way care is delivered. Increasing costs, inconsistent quality, and inadequate access to healthcare create the need for innovation. Companies that address these issues stand to create tremendous value while improving people’s lives across the country and around the world. Waterline is based in Cambridge, MA.

About Bluestem

Bluestem is a Midwest private equity firm with over $360 million of cumulative committed capital. Bluestem’s 30-plus investment projects and funds have invested in more than 100 companies nationwide since its beginning 21 years ago. Bluestem strives to identify investments with attractive returns while helping talented management teams grow their companies and build significant value. Learn more about Bluestem here.